Valid 02/2002 - 04/2002

Aldrich Chemical Co., Inc.
1001 West St. Paul
Milwaukee, WI 53233 USA
Tel: 414-273-3850





             M A T E R I A L  S A F E T Y  D A T A  S H E E T
             
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            493732
    NAME:                 1,4-BUTANEDIOL, 99%
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #:   110-63-4
    MF: C4H10O2
    EC NO:  203-786-5
  SYNONYMS
    AGRISYNTH B1D * BUTANEDIOL * BUTANE-1,4-DIOL * 1,4-BUTYLENE GLYCOL *
    1,4-DIHYDROXYBUTANE * DIOL 14B * SUCOL B * TETRAMETHYLENE 1,4-DIOL *
    1,4-TETRAMETHYLENE GLYCOL *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
  LABEL PRECAUTIONARY STATEMENTS
    IRRITANT
    IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
    TARGET ORGAN(S):
    KIDNEYS
    CENTRAL NERVOUS SYSTEM
    IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
    WATER AND SEEK MEDICAL ADVICE.
    WEAR SUITABLE GLOVES AND EYE/FACE PROTECTION.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN.
    IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
    RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
    AMOUNTS OF WATER.
    IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF
    WATER FOR AT LEAST 15 MINUTES.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
  EXTINGUISHING MEDIA
    WATER SPRAY.
    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
  SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
  UNUSUAL FIRE AND EXPLOSIONS HAZARDS
    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    COVER WITH DRY LIME OR SODA ASH, PICK UP, KEEP IN A CLOSED CONTAINER
    AND HOLD FOR WASTE DISPOSAL.
    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    NIOSH/MSHA-APPROVED RESPIRATOR.
    COMPATIBLE CHEMICAL-RESISTANT GLOVES.
    CHEMICAL SAFETY GOGGLES.
    SAFETY SHOWER AND EYE BATH.
    MECHANICAL EXHAUST REQUIRED.
    DO NOT BREATHE VAPOR.
    AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
    AVOID PROLONGED OR REPEATED EXPOSURE.
    WASH THOROUGHLY AFTER HANDLING.
    WASH CONTAMINATED CLOTHING BEFORE REUSE.
    IRRITANT.
    HARMFUL LIQUID AND FUMES.
    KEEP TIGHTLY CLOSED.
    STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
  PHYSICAL PROPERTIES
    BOILING POINT:        230 C
    FLASHPOINT                >230
    SPECIFIC GRAVITY:     1.017
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
  INCOMPATIBILITIES
    STRONG OXIDIZING AGENTS
    ACID CHLORIDES
    ACID ANHYDRIDES
    REDUCING AGENTS
  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    CARBON MONOXIDE, CARBON DIOXIDE
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
  ACUTE EFFECTS
    CAUSES SKIN IRRITATION.
    MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
    MAY BE HARMFUL IF INHALED.
    HARMFUL IF SWALLOWED.
    VAPOR OR MIST IS IRRITATING TO THE EYES, MUCOUS MEMBRANES AND UPPER
    RESPIRATORY TRACT.
    TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
    TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
  CHRONIC EFFECTS
    TARGET ORGAN(S):
    KIDNEYS
    CENTRAL NERVOUS SYSTEM
  RTECS #: EK0525000
    1,4-BUTANEDIOL
  TOXICITY DATA
    UNR-WMN LDLO:300 MG/KG                        PHARAT 3,110,1948
    REC-MAN LDLO:429 MG/KG                        PHARAT 3,110,1948
    ORL-RAT LD50:1525 MG/KG                       HYSAAV
     33(1-3),41,1968
    IPR-RAT LD50:1070 MG/KG                       JPPMAB 26,597,1974
    ORL-MUS LD50:2062 MG/KG                       HYSAAV
     33(1-3),41,1968
    IPR-MUS LD50:1650 MG/KG                       TXAPA9 49,385,1979
    ORL-RBT LD50:2531 MG/KG                       HYSAAV
     33(1-3),41,1968
    ORL-GPG LD50:1200 MG/KG                       HYSAAV
     33(1-3),41,1968
  TARGET ORGAN DATA
    SENSE ORGANS AND SPECIAL SENSES (OTHER OLFACTION EFFECTS)
    BEHAVIORAL (ALTERED SLEEP TIME)
    BEHAVIORAL (SOMNOLENCE)
    LUNGS, THORAX OR RESPIRATION (OTHER CHANGES)
    BLOOD (OTHER CHANGES)
    NUTRITIONAL AND GROSS METABOLIC (WEIGHT LOSS OR DECREASED WEIGHT GAIN)
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT ALDRICH CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
  EUROPEAN INFORMATION
    IRRITANT
    R 36/37/38
    IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
    S 26
    IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
    WATER AND SEEK MEDICAL ADVICE.
    S 37/39
    WEAR SUITABLE GLOVES AND EYE/FACE PROTECTION.
  TLV AND SOURCE
    FOR 1,4-BUTANEDIOL:
    MANUFACTURER'S EXPOSURE LIMIT: 30 PPM, 8 & 12 HR. TWA
  REVIEWS, STANDARDS, AND REGULATIONS
    OEL=MAK
    NOHS 1974: HZD M0752; NIS 7; TNF 226; NOS 22; TNE 16785
    NOES 1983: HZD M0752; NIS 21; TNF 759; NOS 25; TNE 16811; TFE 3870
    EPA GENETOX PROGRAM 1988, INCONCLUSIVE: D MELANOGASTER SEX-LINKED
     LETHAL
    EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
    EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
    EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
    NTP TOXICITY STUDIES, RPT# TOX-54, OCTOBER 2000
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
    COPYRIGHT 2001 SIGMA-ALDRICH CO.
    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY