Valid 11/2001 - 01/2002

Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Tel: 314-771-5765





             M A T E R I A L  S A F E T Y  D A T A  S H E E T
             
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            DN25
    NAME:                 DEOXYRIBONUCLEASE I CRUDE
                          LYOPHILIZED POWDER
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #:  9003-98-9
    EC NO:  232-667-0
  SYNONYMS
    ALKALINE DEOXYRIBONUCLEASE * ALKALINE DNASE * DEOXYRIBONUCLEASE *
    DEOXYRIBONUCLEASE A * DEOXYRIBONUCLEASE I * DEOXYRIBONUCLEASE
    (PANCREATIC) * DEOXYRIBONUCLEIC PHOSPHATASE * DESOXYRIBONUCLEASE *
    DNAASE * DNA DEPOLYMERASE * DNA ENDONUCLEASE * DNA NUCLEASE * DNASW *
    DNASE I * DORNASE * DORNAVA * DORNAVAC * E.C. 3.1.4.5 *
    ENDODEOXYRIBONUCLEASE I * ESCHERICHIA COLI ENDONUCLEASE I *
    PANCREATIC DEOXYRIBONUCLEASE * PANCREATIC DORNASE *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
  LABEL PRECAUTIONARY STATEMENTS
    CAUTION:
    AVOID CONTACT AND INHALATION.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN.
    IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,
    CALL A PHYSICIAN.
    IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
    AMOUNTS OF WATER.
    IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
    THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
  EXTINGUISHING MEDIA
    USE EXTINGUISHING MEDIA APPROPRIATE TO SURROUNDING FIRE CONDITIONS.
  SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
    AVOID RAISING DUST.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    SAFETY SHOWER AND EYE BATH.
    AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
    AVOID INHALATION.
    AVOID PROLONGED OR REPEATED EXPOSURE.
    NIOSH/MSHA-APPROVED RESPIRATOR.
    COMPATIBLE CHEMICAL-RESISTANT GLOVES.
    CHEMICAL SAFETY GOGGLES.
    WASH THOROUGHLY AFTER HANDLING.
    KEEP CONTAINER CLOSED.
    STORE AWAY FROM HEAT.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
    DATA NOT AVAILABLE
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
  STABILITY
    STABLE.
  INCOMPATIBILITIES
    STRONG OXIDIZING AGENTS
  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    NATURE OF DECOMPOSITION PRODUCTS NOT KNOWN.
  HAZARDOUS POLYMERIZATION
    WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
  ACUTE EFFECTS
    MAY CAUSE SKIN IRRITATION.
    MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
    MAY CAUSE EYE IRRITATION.
    MAY BE HARMFUL IF INHALED.
    MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER
    RESPIRATORY TRACT.
    MAY BE HARMFUL IF SWALLOWED.
    PROLONGED OR REPEATED EXPOSURE MAY CAUSE ALLERGIC REACTIONS IN CERTAIN
    SENSITIVE INDIVIDUALS.
    TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
    TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
  RTECS #: RF0750000
    NUCLEASE, DEOXYRIBO-
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
  REVIEWS, STANDARDS, AND REGULATIONS
    OEL=MAK
    NOHS 1974: HZD 81370; NIS 1; TNF 181; NOS 5; TNE 1471
    NOES 1983: HZD 81370; NIS 1; TNF 116; NOS 5; TNE 8763; TFE 8131
    EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
    COPYRIGHT 2001 SIGMA-ALDRICH CO.
    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY