Valid 02/2002 - 04/2002

Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Tel: 314-771-5765





             M A T E R I A L  S A F E T Y  D A T A  S H E E T
             
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            E2129
    NAME:                 EVANS BLUE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #:   314-13-6
    MF: C34H24N6NA4O14S4
    EC NO:  206-242-5
  SYNONYMS
    AZOVAN BLUE * 4,4'-BIS(1-AMINO-8-HYDROXY-2,4-DISULFO-7-NAPHTHYLAZO)-3,
    3'-BITOLYL, TETRASODIUM SALT * 4,4'-BIS(7-(1-AMINO-8-HYDROXY-2,4-
    DISULFO)NAPHTHYLAZO)-3,3'-BITOLYL, TETRASODIUM SALT * 4,4'-BIS(1-
    AMINO-8-HYDROXY-2,4-DISULPHO-7-NAPHTHYLAZO)-3,3'-BITOLYL, TETRASODIUM
    SALT * 4,4'-BIS(7-(1-AMINO-8-HYDROXY-2,4-DISULPHO)NAPHTHYLAZO)-3,3'-
    BITOLYL, TETRASODIUM SALT * BLEKIT EVANSA (POLISH) * C.I. 23860 * C.I.
     DIRECT BLUE 53 * C.I. DIRECT BLUE 53, TETRASODIUM SALT * DIAMINE SKY
    BLUE FF * DIAZOBLEU * DIAZOL PURE BLUE BF * DIRECT BLUE 53 * DYE
    EVANS BLUE * EVABLIN * EVANS BLUE * EVANS BLUE DYE * EVANS BLUE,
    SODIUM SALT * GEIGY-BLAU 536 * GEIGY BLUE 536, MED * MODR EVANSOVA
    (CZECH) * MODR PRIMA 53 (CZECH) * T 1824 *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
  LABEL PRECAUTIONARY STATEMENTS
    TOXIC
    MAY CAUSE HARM TO THE UNBORN CHILD.
    HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
    POSSIBLE CARCINOGEN.
    TARGET ORGAN(S):
    LIVER
    IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
    IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
    WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
    PROTECTION.
    DO NOT BREATHE DUST.
    KEEP CONTAINER TIGHTLY CLOSED IN A COOL WELL-VENTILATED PLACE.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH COPIOUS
    AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED
    CLOTHING AND SHOES.
    IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
    RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN.
    DISCARD CONTAMINATED CLOTHING AND SHOES.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
  EXTINGUISHING MEDIA
    WATER SPRAY.
    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
  SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
  UNUSUAL FIRE AND EXPLOSIONS HAZARDS
    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    EVACUATE AREA.
    WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    WEAR DISPOSABLE COVERALLS AND DISCARD THEM AFTER USE.
    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
    GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
    SAFETY SHOWER AND EYE BATH.
    USE ONLY IN A CHEMICAL FUME HOOD.
    DO NOT BREATHE DUST.
    AVOID ALL CONTACT.
    WASH THOROUGHLY AFTER HANDLING.
    POSSIBLE CARCINOGEN.
    TERATOGEN.
    HARMFUL SOLID.
    KEEP TIGHTLY CLOSED.
    STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
  APPEARANCE AND ODOR
    DARK-BROWN POWDER
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
  INCOMPATIBILITIES
    STRONG OXIDIZING AGENTS
  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    TOXIC FUMES OF:
    CARBON MONOXIDE, CARBON DIOXIDE
    NITROGEN OXIDES
    SULFUR OXIDES
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
  ACUTE EFFECTS
    HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN.
    MAY CAUSE IRRITATION.
  CHRONIC EFFECTS
    POSSIBLE CARCINOGEN.
    OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDER(S) BASED ON TESTS WITH
    LABORATORY ANIMALS.
    TARGET ORGAN(S):
    LIVER
    TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
    TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
  RTECS #: QJ6440000
    1,3-NAPHTHALENEDISULFONIC ACID,
     6,6'-((3,3'-DIMETHYL-4,4'-BIPHENYLYLENE)BIS(AZO))BIS
    (4-AMINO-5-HYDROXY-, TETRASODIUM SALT
  TOXICITY DATA
    IPR-MUS LD50:340 MG/KG                        BBRCA9 136,64,1986
  TARGET ORGAN DATA
    LIVER (TUMORS)
    BLOOD (LEUKEMIA)
    EFFECTS ON FERTILITY (POST-IMPLANTATION MORTALITY)
    EFFECTS ON EMBRYO OR FETUS (FETOTOXICITY)
    EFFECTS ON EMBRYO OR FETUS (OTHER EFFECTS TO EMBYRO OR FETUS)
    SPECIFIC DEVELOPMENTAL ABNORMALITIES (CENTRAL NERVOUS SYSTEM)
    SPECIFIC DEVELOPMENTAL ABNORMALITIES (EYE, EAR)
    TUMORIGENIC (EQUIVOCAL TUMORIGENIC AGENT BY RTECS CRITERIA)
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
  EUROPEAN INFORMATION
    TOXIC
    R 61
    MAY CAUSE HARM TO THE UNBORN CHILD.
    R 20/21/22
    HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED.
    S 45
    IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
    IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
    S 36/37/39
    WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
    PROTECTION.
    S 22
    DO NOT BREATHE DUST.
    S 3/7/9
    KEEP CONTAINER TIGHTLY CLOSED IN A COOL WELL-VENTILATED PLACE.
  REVIEWS, STANDARDS, AND REGULATIONS
    OEL=MAK
    IARC CANCER REVIEW:ANIMAL LIMITED EVIDENCE    IMEMDT 8,151,1975
    IARC CANCER REVIEW:HUMAN NO ADEQUATE DATA     IMEMDT 8,151,1975
    IARC CANCER REVIEW:GROUP 3                    IMSUDL 7,56,1987
    NOES 1983: HZD T0844; NIS 3; TNF 162; NOS 6; TNE 5350; TFE 2829
    EPA GENETOX PROGRAM 1988, INCONCLUSIVE: HISTIDINE REVERSION-AMES TEST
    EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
    EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
    COPYRIGHT 2001 SIGMA-ALDRICH CO.
    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY