Valid 02/2002 - 04/2002

Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Tel: 314-771-5765





             M A T E R I A L  S A F E T Y  D A T A  S H E E T
             
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            F6886
    NAME:                 FORSKOLIN FROM COLEUS FORSKOHLII
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #: 66575-29-9
    MF: C22H34O7
    EC NO:  266-410-9
  SYNONYMS
    7-BETA-ACETOXY-8,13-EPOXY-1-ALPHA,6-BETA,9-ALPHA-TRIHYDROXYLABD-14-EN-
    11-ONE * COLEONOL * COLFORSIN * FORSKOLIN *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
  LABEL PRECAUTIONARY STATEMENTS
    HARMFUL
    HARMFUL IN CONTACT WITH SKIN.
    TARGET ORGAN(S):
    SMOOTH MUSCLE
    WEAR SUITABLE PROTECTIVE CLOTHING.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN.
    IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
    SHOES. CALL A PHYSICIAN.
    IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,
    CALL A PHYSICIAN.
    IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
    THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
  EXTINGUISHING MEDIA
    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
    WATER SPRAY.
  SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    NIOSH/MSHA-APPROVED RESPIRATOR.
    MECHANICAL EXHAUST.
    COMPATIBLE CHEMICAL-RESISTANT GLOVES.
    CHEMICAL SAFETY GOGGLES.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
  APPEARANCE AND ODOR
    SOLID.
  PHYSICAL PROPERTIES
    SOLUBILITY:
                                              ETHANOL -SOLUBLE
                                             SOLUBLE METHANOL
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
  STABILITY
    STABLE.
  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    TOXIC FUMES OF:
    CARBON MONOXIDE, CARBON DIOXIDE
  HAZARDOUS POLYMERIZATION
    WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
  ACUTE EFFECTS
    HARMFUL IF ABSORBED THROUGH SKIN.
    FORSKOLIN HAS  ANTIHYPERTENSIVE, POSITIVE INOTROPIC, PLATELET
    AGGREGATION INHIBITORY AND ADENYLCYCLASE ACTIVATING PROPERTIES. *
    TARGET ORGAN(S):
    SMOOTH MUSCLE
    THE TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY
    INVESTIGATED.
  ADDITIONAL INFORMATION
    * DE SOUZA, N.J., ET AL., MED. RES. REV., 3,201 (1983).
  RTECS #: QL6150000
    1H-NAPHTHO(2,1-B)PYRAN-1-ONE,
     DODECAHYDRO-5-(ACETYLOXY)-3-ETHENYL-3,4A,7,7,10A-PENTAMETHYL-
    6,10,10B-TRIHYDROXY-,
     (3R-(3-ALPHA,4A-BETA,5-BETA,6-BETA,6A-ALPHA,10-ALPHA,10A-BETA,10B-
    ALPHA))-
  TOXICITY DATA
    ORL-RAT LD50:2550 MG/KG                       MRREDD 3,201,1983
    IPR-RAT LD50:92 MG/KG                         JMCMAR 31,1872,1988
    ORL-MUS LD50:3100 MG/KG                       MRREDD 3,201,1983
    IPR-MUS LD50:68 MG/KG                         JOETD7 3,1,1981
  TARGET ORGAN DATA
    BEHAVIORAL (CHANGE IN MOTOR ACTIVITY)
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
  EUROPEAN INFORMATION
    HARMFUL
    R 21
    HARMFUL IN CONTACT WITH SKIN.
    S 36
    WEAR SUITABLE PROTECTIVE CLOTHING.
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
    COPYRIGHT 2001 SIGMA-ALDRICH CO.
    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY