Valid 02/2002 - 04/2002

Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Tel: 314-771-5765





             M A T E R I A L  S A F E T Y  D A T A  S H E E T
             
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            I0125
    NAME:                 IMIDAZOLE APPROX. 99%
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #:   288-32-4
    MF: C3H4N2
    EC NO:  206-019-2
  SYNONYMS
    1,3-DIAZA-2,4-CYCLOPENTADIENE * 1,3-DIAZOLE * FORMAMIDINE, N,N'-
    VINYLENE- * GLIOKSAL (POLISH) * GLYOXALIN * GLYOXALINE * IMIDAZOL *
    IMINAZOLE * IMUTEX * MIAZOLE * PYRRO(B)MONAZOLE * USAF EK-4733 *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
  LABEL PRECAUTIONARY STATEMENTS
    CORROSIVE
    HARMFUL IF SWALLOWED.
    CAUSES BURNS.
    IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
    WATER AND SEEK MEDICAL ADVICE.
    WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
    PROTECTION.
    IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
    IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN IMMEDIATELY.
    DO NOT INDUCE VOMITING.
    IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
    RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
    SHOES. CALL A PHYSICIAN.
    IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
    THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
  EXTINGUISHING MEDIA
    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
  SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
  UNUSUAL FIRE AND EXPLOSIONS HAZARDS
    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
    EVACUATE AREA.
    AVOID CONTAMINATING SEWERS AND WATERWAYS WITH THIS MATERIAL.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    SAFETY SHOWER AND EYE BATH.
    USE ONLY IN A CHEMICAL FUME HOOD.
    WASH CONTAMINATED CLOTHING BEFORE REUSE.
    DISCARD CONTAMINATED SHOES.
    WASH THOROUGHLY AFTER HANDLING.
    DO NOT BREATHE DUST.
    DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
    AVOID PROLONGED OR REPEATED EXPOSURE.
    NIOSH/MSHA-APPROVED RESPIRATOR.
    COMPATIBLE CHEMICAL-RESISTANT GLOVES.
    CHEMICAL SAFETY GOGGLES.
    KEEP TIGHTLY CLOSED.
    STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
  APPEARANCE AND ODOR
    SOLID.
  PHYSICAL PROPERTIES
    BOILING POINT:        256  C
    MELTING POINT:      85 - 93  C
    FLASHPOINT               293F
                             145C
    SOLUBILITY:
           WATER -Z26130
    PH:                      9.5 - 11.0
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
  STABILITY
    STABLE.
  INCOMPATIBILITIES
    ACIDS
    ACID ANHYDRIDES
    STRONG OXIDIZING AGENTS
  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    CARBON MONOXIDE, CARBON DIOXIDE
    NITROGEN OXIDES
    HYDROGEN CYANIDE
    AMMONIA
  HAZARDOUS POLYMERIZATION
    WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
  ACUTE EFFECTS
    INHALATION MAY RESULT IN SPASM, INFLAMMATION AND EDEMA OF THE
    LARYNX AND BRONCHI, CHEMICAL PNEUMONITIS AND PULMONARY EDEMA.
    SYMPTOMS OF EXPOSURE MAY INCLUDE BURNING SENSATION, COUGHING,
    WHEEZING, LARYNGITIS, SHORTNESS OF BREATH, HEADACHE, NAUSEA AND
    VOMITING.
    MATERIAL IS EXTREMELY DESTRUCTIVE TO TISSUE OF THE MUCOUS MEMBRANES
    AND UPPER RESPIRATORY TRACT, EYES AND SKIN.
    TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
    TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
    CAUSES BURNS.
    MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
    MAY BE HARMFUL IF INHALED.
    MATERIAL IS EXTREMELY DESTRUCTIVE TO THE TISSUE OF THE MUCOUS MEMBRANES
    AND UPPER RESPIRATORY TRACT.
    HARMFUL IF SWALLOWED.
  RTECS #: NI3325000
    IMIDAZOLE
  TOXICITY DATA
    ORL-RAT LD50:220 MG/KG                        PREPAB 67,295,1993
    SCU-RAT LD50:626 MG/KG                        JPETAB 119,444,1957
    ORL-MUS LD50:880 MG/KG                        GWXXBX #3046325
    IPR-MUS LD50:300 MG/KG                        NTIS** AD277-689
    SCU-MUS LD50:817 MG/KG                        JPETAB 119,444,1957
    IVN-MUS LD50:475 MG/KG                        ARZNAD 33,716,1983
    SCU-DOG LD50:28 MG/KG                         PREPAB 67,295,1993
    ORL-GPG LD50:760 MG/KG                        PREPAB 67,295,1993
    ORL-MAM LD50:1 GM/KG                          PCOC** -,608,1966
  TARGET ORGAN DATA
    BEHAVIORAL (CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD)
    BEHAVIORAL (FOOD INTAKE)
    BEHAVIORAL (RIGIDITY)
    PATERNAL EFFECTS (IMPOTENCE)
    NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE DECREASE)
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
    THIS MATERIAL.
    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
  EUROPEAN INFORMATION
    CORROSIVE
    R 22
    HARMFUL IF SWALLOWED.
    R 34
    CAUSES BURNS.
    S 26
    IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
    WATER AND SEEK MEDICAL ADVICE.
    S 36/37/39
    WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
    PROTECTION.
    S 45
    IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE
    IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE).
  REVIEWS, STANDARDS, AND REGULATIONS
    OEL=MAK
    NOHS 1974: HZD M1601; NIS 3; TNF 158; NOS 5; TNE 1401
    NOES 1983: HZD M1601; NIS 3; TNF 313; NOS 4; TNE 3009; TFE 2411
    EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
    EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
    EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
    COPYRIGHT 2001 SIGMA-ALDRICH CO.
    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY