Valid 05/2001 - 07/2001

Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Tel: 314-771-5765





             M A T E R I A L  S A F E T Y  D A T A  S H E E T
             
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            M8777
    NAME:                 MORPHINE SULFATE--DEA SCHEDULE II ITEM
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #:  6211-15-0
    MF: C34H40N2O10S
  SYNONYMS
    4,5-ALPHA-EPOXY-17-METHYLMORPHINAN-3,5-ALPHA-DIOL SULFATE HYDRATE (2:
    1:5) * MORPHINE SULFATE PENTAHYDRATE *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
  LABEL PRECAUTIONARY STATEMENTS
    HARMFUL
    HARMFUL IF SWALLOWED.
    TARGET ORGAN(S):
    CENTRAL NERVOUS SYSTEM
    WEAR SUITABLE PROTECTIVE CLOTHING.
    DO NOT BREATHE DUST.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN.
    IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
    RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
    SHOES. CALL A PHYSICIAN.
    IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
    THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
  EXTINGUISHING MEDIA
    WATER SPRAY.
    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
  SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
  UNUSUAL FIRE AND EXPLOSIONS HAZARDS
    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
    AVOID RAISING DUST.
    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
    EVACUATE AREA.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    SAFETY SHOWER AND EYE BATH.
    MECHANICAL EXHAUST REQUIRED.
    WASH THOROUGHLY AFTER HANDLING.
    DO NOT BREATHE DUST.
    AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
    AVOID PROLONGED OR REPEATED EXPOSURE.
    NIOSH/MSHA-APPROVED RESPIRATOR.
    COMPATIBLE CHEMICAL-RESISTANT GLOVES.
    CHEMICAL SAFETY GOGGLES.
    STORE IN A COOL DRY PLACE.
    KEEP TIGHTLY CLOSED.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
  APPEARANCE AND ODOR
    SOLID.
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
  STABILITY
    STABLE.
  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    CARBON MONOXIDE, CARBON DIOXIDE
    NITROGEN OXIDES
    SULFUR OXIDES
  HAZARDOUS POLYMERIZATION
    WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
  ACUTE EFFECTS
    MAY CAUSE SKIN IRRITATION.
    MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
    MAY CAUSE EYE IRRITATION.
    MAY BE HARMFUL IF INHALED.
    MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER
    RESPIRATORY TRACT.
    HARMFUL IF SWALLOWED.
    PROLONGED OR REPEATED EXPOSURE CAN LEAD TO HABITUATION OR ADDICTION.
    EXPOSURE CAN CAUSE NAUSEA, VOMITING, DIZZINESS, SEDATION, CONSTIPATION,
    DROWSINESS, CONFUSION, CONTACT DERMATITIS, PALPITATIONS, FACIAL
    FLUSHING, AND CNS DEPRESSION.
    OVEREXPOSURE CAN CAUSE RESPIRATORY DEPRESSION, HYPOTENSION, CIRCULATORY
    DEPRESSION AND FAILURE, SHOCK, COMA, CARDIAC ARREST, AND DEATH.
  CHRONIC EFFECTS
    REPEATED EXPOSURE DURING PREGNANCY MAY LEAD TO NEONATAL WITHDRAWAL
    SYMPTOMS
    TARGET ORGAN(S):
    CENTRAL NERVOUS SYSTEM
  RTECS #: QC8760000
    MORPHINAN-3,6-DIOL,
     7,8-DIDEHYDRO-4,5-EPOXY-17-METHYL-(5-ALPHA,6-ALPHA)-,
    SULFATE (2:1) (SALT), PENTAHDRATE
  TOXICITY DATA
    ORL-RAT LD50:973 MG/KG                        IYKEDH 20,228,1989
    ORL-MUS LD50:1125 MG/KG                       IYKEDH 20,228,1989
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    CONTACT THE DRUG ENFORCEMENT ADMINISTRATION CONCERNING THE DISPOSAL
    OF CONTROLLED SUBSTANCES.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
  EUROPEAN INFORMATION
    CAUTION: SUBSTANCE NOT YET FULLY TESTED.
    HARMFUL
    R 22
    HARMFUL IF SWALLOWED.
    S 36
    WEAR SUITABLE PROTECTIVE CLOTHING.
    S 22
    DO NOT BREATHE DUST.
  REVIEWS, STANDARDS, AND REGULATIONS
    OEL=MAK
    NOES 1983: HZD X7173; NIS 1; TNF 25; NOS 1; TNE 1358; TFE 956
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
    COPYRIGHT 2001 SIGMA-ALDRICH CO.
    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY