Valid 02/2002 - 04/2002

Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Tel: 314-771-5765





             M A T E R I A L  S A F E T Y  D A T A  S H E E T
             
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            PVP40
    NAME:                 POLYVINYLPYRROLIDONE AV. MOL.
                          WT. 40,000
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #:  9003-39-8
  SYNONYMS
    AGENT AT 717 * AGRIMER * ALBIGEN A * ALDACOL Q * AT 717 * BOLINAN * 1-
    ETHENYL-2-PYRROLIDINONE POLYMERS * GANEX P 804 * HEMODESIS * HEMODEZ *
     K15 * K25 * K25 (POLYMER) * K30 * K30 (POLYMER) * K60 * K60 (POLYMER)
     * K90 * K115 * K115 (POLYAMIDE) * KOLLIDON * KOLLIDON 17 * KOLLIDON
    25 * KOLLIDON 30 * LUVISKOL * LUVISKOL K30 * LUVISKOL K90 * MPK 90 *
    NCI C60582 * NEOCOMPENSAN * PERAGAL ST * PEREGAL ST * PERISTON *
    PERISTON-N * PEVISTON * PLASDONE * PLASDONE K-26/28 * PLASDONE K 29-
    32 * PLASDONE XL * PLASMOSAN * POLYCLAR AT * POLYCLAR H * POLYCLAR L *
     POLY(1-(2-OXO-1-PYRROLIDINYL)ETHYLENE) * POLYVIDONE * POLY(N-
    VINYLBUTYROLACTAM) * POLY(VINYLPYRROLIDINONE) * POLY(N-
    VINYLPYRROLIDINONE) * POLY(1-VINYLPYRROLIDINONE) *
    POLYVINYLPYRROLIDONE * POVIDONE * POVIDONE (USP XIX) * PROTAGENT *
    PVP * PVP 40 * PVP-K 15 * PVP-K 30 * PVP-K 60 * PVP-K 90 * PVPP * 2-
    PYRROLIDINONE, 1-ETHENYL, HOMOPOLYMER * 2-PYRROLIDINONE, 1-VINYL-,
    POLYMERS * 143 RP * SUBTOSAN * VINISIL * N-VINYLBUTYROLACTAM POLYMER *
     VINYLPYRROLIDINONE POLYMER * N-VINYLPYRROLIDINONE POLYMER * N-
    VINYLPYRROLIDONE POLYMER * VINYLPYRROLIDONE POLYMER *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
  LABEL PRECAUTIONARY STATEMENTS
    CAUTION:
    AVOID CONTACT AND INHALATION.
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN.
    IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,
    CALL A PHYSICIAN.
    IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
    AMOUNTS OF WATER.
    IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
    THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
  EXTINGUISHING MEDIA
    WATER SPRAY.
    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
  SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
  UNUSUAL FIRE AND EXPLOSIONS HAZARDS
    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
    AVOID RAISING DUST.
    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    SAFETY SHOWER AND EYE BATH.
    MECHANICAL EXHAUST REQUIRED.
    AVOID INHALATION.
    AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
    AVOID PROLONGED OR REPEATED EXPOSURE.
    NIOSH/MSHA-APPROVED RESPIRATOR.
    COMPATIBLE CHEMICAL-RESISTANT GLOVES.
    CHEMICAL SAFETY GOGGLES.
    KEEP TIGHTLY CLOSED.
    STORE IN A COOL DRY PLACE.
    WASH THOROUGHLY AFTER HANDLING.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
  APPEARANCE AND ODOR
    SOLID.
  PHYSICAL PROPERTIES
    MELTING POINT:      300  C
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
  STABILITY
    STABLE.
  INCOMPATIBILITIES
    STRONG OXIDIZING AGENTS
  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    CARBON MONOXIDE, CARBON DIOXIDE
    NITROGEN OXIDES
  HAZARDOUS POLYMERIZATION
    WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
  ACUTE EFFECTS
    MAY CAUSE SKIN IRRITATION.
    MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
    MAY CAUSE EYE IRRITATION.
    MAY BE HARMFUL IF INHALED.
    MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER
    RESPIRATORY TRACT.
    MAY BE HARMFUL IF SWALLOWED.
    UNEXCRETED PARTICLES MAY BE PHAGOCYTIZED BY CELLS OF THE
    RETICULOENDOTHELIAL SYSTEM AND DEPOSITED IN STORAGE SITES IN THE LIVER,
    SPLEEN, LUNG, BONE MARROW RESULTING IN THE STORAGE DISEASE THESAUROSIS.
    SEVERITY AND SYMPTOMS DEPEND ON STORAGE SITE AND NATURE OF THE PARTICLE.
    PATHOLOGICAL CHANGES ARE NOT NECESSARILY ATTRIBUTED TO THE THESAUROSIS,
    BUT IN SOME CASES AN INFLAMMATION OR GRANULOMATOMA HAVE OCCURRED.
  CHRONIC EFFECTS
    THIS PRODUCT IS OR CONTAINS A COMPONENT THAT IS NOT CLASSIFIABLE AS
    TO ITS CARCINOGENICITY BASED ON ITS IARC, ACGIH, NTP OR EPA
    CLASSIFICATION.
  RTECS #: TR8370000
    POLY(1-VINYL-2-PYRROLIDINONE) HOMOPOLYMER
  TOXICITY DATA
    ORL-RAT LD50:100 GM/KG                        FAONAU 53A,486,1974
    ORL-MUS LD50:>40 GM/KG                        FAONAU 40,164,1967
    IPR-MUS LD50:12 GM/KG                         FAONAU 53A,486,1974
    UNR-MUS LD50:16 GM/KG                         KHFZAN 19,212,1985
    ORL-RBT LD50:1040 MG/KG                       VETNAL 61(12),68,1985
    ORL-GPG LD50:100 GM/KG                        FAONAU 53A,486,1974
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
    THIS MATERIAL.
    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
  EUROPEAN INFORMATION
    CAUTION: SUBSTANCE NOT YET FULLY TESTED.
    S 22
    DO NOT BREATHE DUST.
    S 24/25
    AVOID CONTACT WITH SKIN AND EYES.
  REVIEWS, STANDARDS, AND REGULATIONS
    OEL=MAK
    IARC CANCER REVIEW:ANIMAL LIMITED EVIDENCE    IMEMDT 19,461,1979
    IARC CANCER REVIEW:ANIMAL LIMITED EVIDENCE    IMEMDT 71,1181,1999
    IARC CANCER REVIEW:HUMAN NO ADEQUATE DATA     IMEMDT 19,461,1979
    IARC CANCER REVIEW:HUMAN NO ADEQUATE DATA     IMEMDT 71,1181,1999
    IARC CANCER REVIEW:GROUP 3                    IMEMDT 71,1181,1999
    NOHS 1974: HZD 81235; NIS 50; TNF 7856; NOS 63; TNE 102100
    NOES 1983: HZD X7211; NIS 46; TNF 7688; NOS 63; TNE 161259; TFE 84819
    EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
    EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
    EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
    COPYRIGHT 2001 SIGMA-ALDRICH CO.
    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY