**** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****
MSDS Name: Tris(hydroxymethyl)aminomethane
Catalog Numbers:
S80234, BP152 1, BP152 10, BP152 25, BP152 5,
BP152 500, BP152-1, BP152-25,
BP152-5, BP152-500, BP1521, BP15210, BP15225,
BP1525, BP152500, BP154 1,
BP1541, T370 3, T370 500, T370-3, T370-500,
T3703, T370500, T393-12,
T393-212, T393-500, T393212, T395 1, T395 100,
T395 500, T395-1, T395-100,
T395-500, T3951, T395100, T395500
Synonyms:
THAM; Tris; Trisaminol; Trismethylolaminomethane;
2-amino-2-(hydroxymethyl) propane-1,3-diol
Company Identification: Fisher Scientific
1 Reagent Lane
Fairlawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS#
|
Chemical Name
| % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 77-86-1 |Tris (hydroxymethyl)
aminomethane | ~ 100 | 201-064-4
|
+----------------+--------------------------------------+----------+-----------+
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Appearance: white.
Caution! The toxicological properties of this material have not
been
fully investigated. May cause eye and skin irritation. May cause
liver and kidney damage. May cause respiratory and digestive tract
irritation.
Target Organs: Kidneys, liver.
Potential Health Effects
Eye:
May cause eye
irritation.
Skin:
May cause skin
irritation.
Ingestion:
May cause severe
gastrointestinal tract irritation with nausea,
vomiting and possible
burns. May cause liver and kidney damage. The
toxicological
properties of this substance have not been fully
investigated.
May cause metabolic changes including hypoglycemia, and
hyperkalemia.
May depress respiratory center.
Inhalation:
May cause irritation
of the respiratory tract with burning pain in
the nose and throat,
coughing, wheezing, shortness of breath and
pulmonary edema.
The toxicological properties of this substance have
not been fully
investigated.
Chronic:
Prolonged or repeated
skin contact may cause dermatitis. May cause
liver and kidney
damage.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with
plenty of water for at least 15 minutes,
occasionally lifting
the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid.
Flush skin with plenty of soap and water for at
least 15 minutes
while removing contaminated clothing and shoes. Wash
clothing before
reuse.
Ingestion:
If victim is conscious
and alert, give 2-4 cupfuls of milk or water.
Never give anything
by mouth to an unconscious person. Get medical
aid.
Inhalation:
Get medical aid
immediately. Remove from exposure to fresh air
immediately. If
not breathing, give artificial respiration. If
breathing is difficult,
give oxygen.
Notes to Physician:
Treat symptomatically
and
Antidote:
None reported.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire,
wear a self-contained breathing apparatus in
pressure-demand,
MSHA/NIOSH (approved or equivalent), and full
protective gear.
During a fire, irritating and highly toxic gases
may be generated
by thermal decomposition or combustion.
Extinguishing Media:
In case of fire,
use water, dry chemical, chemical foam, or
alcohol-resistant
foam.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective
equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills
immediately, observing precautions in the Protective
Equipment section.
Sweep up or absorb material, then place into a
suitable clean,
dry, closed container for disposal. Avoid generating
dusty conditions.
Provide ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly
after handling. Remove contaminated clothing and
wash before reuse.
Use with adequate ventilation. Avoid contact with
eyes, skin, and
clothing. Keep container tightly closed. Avoid
ingestion and
inhalation. Discard contaminated shoes.
Storage:
Store in a tightly
closed container. Store in a cool, dry,
well-ventilated
area away from incompatible substances. Keep away
from acids. Keep
containers tightly closed.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Facilities storing
or utilizing this material should be equipped
with an eyewash
facility and a safety shower. Use adequate
ventilation to
keep airborne concentrations low.
Exposure Limits
+--------------------+-------------------+-------------------+-----------------+
| Chemical Name |
ACGIH |
NIOSH |OSHA - Final PELs|
|--------------------|-------------------|-------------------|-----------------|
| Tris (hydroxymethyl|none listed
|none listed |none listed
|
| ) aminomethane |
|
|
|
+--------------------+-------------------+-------------------+-----------------+
OSHA Vacated PELs:
Tris (hydroxymethyl)
aminomethane:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR §1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant a respirator's use.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State:
Solid
Appearance:
white
Odor:
amine-like
pH:
10.36(aq. solution)
Vapor Pressure:
Not available.
Vapor Density:
Not available.
Evaporation Rate:
Not available.
Viscosity:
Not available.
Boiling Point:
219-220 deg C
Freezing/Melting Point: 171.2-172.3 deg
C
Autoignition Temperature: Not available.
Flash Point:
Not available.
NFPA Rating:
(est.) Health: 1; Flammability: 0; Reactivity: 0
Explosion Limits, Lower: Not available.
Upper: Not available.
Decomposition Temperature: Not available.
Solubility:
Moderately soluble in water.
Specific Gravity/Density: Not available.
Molecular Formula:
(CH2OH)3CNH2
Molecular Weight:
121.0819
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under normal
temperatures and pressures.
Conditions to Avoid:
Incompatible materials,
dust generation.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides,
carbon monoxide, irritating and toxic fumes and
gases, carbon
dioxide, nitrogen.
Hazardous Polymerization: Will not occur.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 77-86-1:
TY2900000
LD50/LC50:
CAS# 77-86-1:
Oral, rat: LD50 = 5900 mg/kg.
Carcinogenicity:
Tris (hydroxymethyl) aminomethane
-
Not listed by
ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology:
No information
available.
Teratogenicity:
No information
available.
Reproductive Effects:
No information
available.
Neurotoxicity:
No information
available.
Mutagenicity:
No information
available.
Other Studies:
No data available.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Other
No information
available.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Chemical waste generators must determine whether a discarded chemical
is classif
as a hazardous waste.
US EPA guidelines for the classification determination are listed
in 40 CFR Part
Additionally, waste generators must consult state and local hazardous
waste regu
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
**** SECTION 14 - TRANSPORT INFORMATION ****
US DOT
No information
available
Canadian TDG
No information
available.
**** SECTION 15 - REGULATORY INFORMATION ****
US FEDERAL
TSCA
CAS# 77-86-1 is
listed on the TSCA inventory.
Health & Safety Reporting
List
None of the chemicals
are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals
in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals
are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals
in this material have a SNUR under TSCA.
SARA
Section 302 (RQ)
None of the chemicals
in this material have an RQ.
Section 302 (TPQ)
None of the chemicals
in this product have a TPQ.
SARA Codes
CAS # 77-86-1:
acute.
Section 313
No chemicals are
reportable under Section 313.
Clean Air Act:
This material
does not contain any hazardous air pollutants.
This material
does not contain any Class 1 Ozone depletors.
This material
does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals
in this product are listed as Hazardous
Substances under
the CWA.
None of the chemicals
in this product are listed as Priority
Pollutants under
the CWA.
None of the chemicals
in this product are listed as Toxic Pollutants
under the CWA.
OSHA:
None of the chemicals
in this product are considered highly hazardous
by OSHA.
STATE
Tris (hydroxymethyl) aminomethane is not present
on state lists from
CA, PA, MN, MA, FL, or NJ.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
Not available.
Risk Phrases:
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 77-86-1:
1
United Kingdom Occupational Exposure Limits
Canada
CAS# 77-86-1 is
listed on Canada's DSL/NDSL List.
This product has
a WHMIS classification of D2B.
CAS# 77-86-1 is
not listed on Canada's Ingredient Disclosure List.
Exposure Limits
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 7/15/1999 Revision #1 Date: 8/02/2000
The information above is believed to be accurate
and represents the best
information currently available to us. However,
we make no warranty of
merchantability or any other warranty, express
or implied, with respect to
such information, and we assume no liability
resulting from its use. Users
should make their own investigations to determine
the suitability of the
information for their particular purposes. In
no way shall the company be
liable for any claims, losses, or damages of
any third party or for lost
profits or any special, indirect, incidental,
consequential or exemplary
damages, howsoever arising, even if the company
has been advised of
the possibility of such damages.
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