Valid 02/2002 - 04/2002
Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Tel: 314-771-5765
M A T E R I A L S A F E T Y D A T A S H E E T
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
CATALOG #: T6066
NAME: TRIZMA BASE, BIOTECHNOLOGY PERFORMANCE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
CAS #: 77-86-1
MF: C4H11NO3
EC NO: 201-064-4
SYNONYMS
ADDEX-THAM * 2-AMINO-2-(HYDROXYMETHYL)PROPANE-1,3-DIOL * 2-AMINO-2-
(HYDROXYMETHYL)-1,3-PROPANEDIOL * 2-AMINO-2-METHYLOL-1,3-PROPANEDIOL *
AMINOTRIMETHYLOLMETHANE * AMINOTRIS(HYDROXYMETHYL)METHANE *
METHYLAMINE, 1,1,1-TRIS(HYDROXYMETHYL)- * PEHANORM * TALATROL * THAM-
E * THAM SET * TRIMETHYLOLAMINOMETHANE * TRIS (BUFFERING AGENT) *
TRISAMINE * TRIS-AMINO * TRISAMINOL * TRIS BUFFER * TRIS-
HYDROXYMETHYL-AMINOMETHAN (GERMAN) * TRIS-HYDROXYMETHYLAMINOMETHANE *
TRIS(HYDROXYMETHYL)METHANAMINE * TRIS(HYDROXYMETHYL)METHYLAMINE *
TRISPUFFER * TRIS-STERIL * TROMETAMOL * TROMETAMOLE * TROMETHAMINE *
TROMETHANE * TROMETHANMIN * TUTOFUSIN TRIS *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
LABEL PRECAUTIONARY STATEMENTS
IRRITANT
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
WEAR SUITABLE PROTECTIVE CLOTHING.
HYGROSCOPIC
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN.
IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
AMOUNTS OF WATER.
IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF
WATER FOR AT LEAST 15 MINUTES.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
EXTINGUISHING MEDIA
WATER SPRAY.
CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
SPECIAL FIREFIGHTING PROCEDURES
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
PREVENT CONTACT WITH SKIN AND EYES.
UNUSUAL FIRE AND EXPLOSIONS HAZARDS
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
RUBBER GLOVES.
SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SWEEP TOGETHER THE WETTED MATERIAL CAREFULLY AND FILL INTO MARKED,
SEALED CONTAINERS.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
SAFETY SHOWER AND EYE BATH.
MECHANICAL EXHAUST REQUIRED.
WASH THOROUGHLY AFTER HANDLING.
DO NOT BREATHE DUST.
AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
AVOID PROLONGED OR REPEATED EXPOSURE.
NIOSH/MSHA-APPROVED RESPIRATOR.
COMPATIBLE CHEMICAL-RESISTANT GLOVES.
CHEMICAL SAFETY GOGGLES.
KEEP TIGHTLY CLOSED.
STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
APPEARANCE AND ODOR
CRYSTALLINE
SOLID.
PHYSICAL PROPERTIES
BOILING POINT: 219 - 220 C
MELTING POINT: 171.2 - 172.3 C
SOLUBILITY:
WATER -Z26130
PH: 10.5 - 12.0
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
STABILITY
STABLE.
INCOMPATIBILITIES
PROTECT FROM MOISTURE.
STRONG OXIDIZING AGENTS
HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
CARBON MONOXIDE, CARBON DIOXIDE
NITROGEN OXIDES
HAZARDOUS POLYMERIZATION
WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
ACUTE EFFECTS
CAUSES SKIN IRRITATION.
MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
CAUSES EYE IRRITATION.
MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
RESPIRATORY TRACT.
MAY BE HARMFUL IF INHALED.
MAY BE HARMFUL IF SWALLOWED.
TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
RTECS #: TY2900000
1,3-PROPANEDIOL, 2-AMINO-2-(HYDROXYMETHYL)-
TOXICITY DATA
ORL-RAT LD50:5900 MG/KG BCFAAI 110,653,1971
IVN-RAT LD50:1800 MG/KG NIIRDN -,419,1990
IVN-MUS LD50:1210 MG/KG ABMGAJ 17,217,1966
TARGET ORGAN DATA
BEHAVIORAL (SOMNOLENCE)
BEHAVIORAL (MUSCLE WEAKNESS)
BEHAVIORAL (COMA)
ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
(RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
THIS MATERIAL.
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
EUROPEAN INFORMATION
IRRITANT
R 36/37/38
IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
S 26
IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
WATER AND SEEK MEDICAL ADVICE.
S 36
WEAR SUITABLE PROTECTIVE CLOTHING.
REVIEWS, STANDARDS, AND REGULATIONS
OEL=MAK
NOHS 1974: HZD 81165; NIS 4; TNF 850; NOS 6; TNE 7274
NOES 1983: HZD 81165; NIS 9; TNF 2296; NOS 22; TNE 40897; TFE 30773
EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
COPYRIGHT 2001 SIGMA-ALDRICH CO.
LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY
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