Valid 02/2002 - 04/2002

Sigma Chemical Co.
P.O. Box 14508
St. Louis, MO 63178 USA
Tel: 314-771-5765





             M A T E R I A L  S A F E T Y  D A T A  S H E E T
             
SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            P5188
    NAME:                 POLYOXYETHYLENESORBITAN MONOOLEATE
                          MOLECULAR BIOLOGY GRADE
SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #:  9005-65-6
  SYNONYMS
    ARMOTAN PMO-20 * ATLOX 1087 * ATLOX 8916TF * CAPMUL POE-O * CRILL 10 *
     CRILL 11 * CRILLET 4 * CRILL S 10 * DREWMULSE POE-SMO * DURFAX 80 *
    EMSORB 6900 * ETHOXYLATED SORBITAN MONOOLEATE * GLYCOSPERSE O-20 *
    GLYCOSPERSE O-20 VEG * GLYCOSPERSE O-20X * HODAG SVO 9 * MO 55F *
    MONITAN * MONTANOX 80 * NCI-C60286 * NIKKOL TO * NIKKOL TO 10 *
    OLOTHORB * POLYETHYLENE OXIDE SORBITAN MONO-OLEATE * POLYOXYETHYLENE
    SORBITAN MONOOLEATE * POLYOXYETHYLENE (20) SORBITAN MONO-OLEATE *
    POLYOXYETHYLENE SORBITAN OLEATE * POLYSORBAN 80 * POLYSORBATE 80 *
    POLYSORBATE 81 * POLYSORBATE 80 B.P.C. * POLYSORBATE 80, U.S.P. *
    PROTASORB O-20 * ROMULGIN O * SORBIMACROGOL OLEATE * SORBIMACROGOL
    OLEATE 300 * SORBITAL 0 20 * SORBITAN MONO-9-OCTADECENOATE POLY(OXY-1,
    2-ETHANEDIYL) DERIVATIVES * SORBON T 80 * SORETHYTAN (20) MONOOLEATE *
     SORLATE * SVO 9 * TO 10 * TWEEN 80 * TWEEN 81 * TWEEN 80 A *
SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
    DATA NOT AVAILABLE
SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
    CALL A PHYSICIAN.
    IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT,
    CALL A PHYSICIAN.
    IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
    AMOUNTS OF WATER.
    IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER
    FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING
    THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.
SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
  EXTINGUISHING MEDIA
    WATER SPRAY.
    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
  SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
  UNUSUAL FIRE AND EXPLOSIONS HAZARDS
    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.
SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    ABSORB ON SAND OR VERMICULITE AND PLACE IN CLOSED CONTAINERS FOR
    DISPOSAL.
    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.
SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.
SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    SAFETY SHOWER AND EYE BATH.
    MECHANICAL EXHAUST REQUIRED.
    WASH THOROUGHLY AFTER HANDLING.
    AVOID INHALATION.
    AVOID CONTACT WITH EYES, SKIN AND CLOTHING.
    AVOID PROLONGED OR REPEATED EXPOSURE.
    NIOSH/MSHA-APPROVED RESPIRATOR.
    COMPATIBLE CHEMICAL-RESISTANT GLOVES.
    CHEMICAL SAFETY GOGGLES.
    KEEP TIGHTLY CLOSED.
    STORE IN A COOL DRY PLACE.
SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
  APPEARANCE AND ODOR
    LIQUID.
  PHYSICAL PROPERTIES
    FLASHPOINT               >302F
                             >150C
    VAPOR PRESSURE:      < 1 MMHG @ 20  C
    SPECIFIC GRAVITY:     1.064
SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
  STABILITY
    STABLE.
  INCOMPATIBILITIES
    BASES
    HEAVY METAL SALTS
    STRONG OXIDIZING AGENTS
  HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    CARBON MONOXIDE, CARBON DIOXIDE
  HAZARDOUS POLYMERIZATION
    WILL NOT OCCUR.
SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
  ACUTE EFFECTS
    MAY CAUSE SKIN IRRITATION.
    MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
    MAY CAUSE EYE IRRITATION.
    MAY BE HARMFUL IF INHALED.
    MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER
    RESPIRATORY TRACT.
    MAY BE HARMFUL IF SWALLOWED.
    TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
    TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
  CHRONIC EFFECTS
    THIS PRODUCT IS OR CONTAINS A COMPONENT THAT IS NOT CLASSIFIABLE AS
    TO ITS CARCINOGENICITY BASED ON ITS IARC, ACGIH, NTP OR EPA
    CLASSIFICATION.
  RTECS #: WG2932500
    SORBITAN, MONOOLEATE POLYOXYETHYLENE DERIV.
  IRRITATION DATA
    EYE-RBT 150 MG MLD                            AROPAW 40,668,1948
  TOXICITY DATA
    ORL-RAT LD50:34500 UL/KG                      FOREAE 21,348,1956
    IPR-RAT LD50:6804 MG/KG                       ARZNAD 35,804,1985
    IVN-RAT LD50:1790 MG/KG                       FAONAU 53A,254,1974
    ORL-MUS LD50:25 GM/KG                         BCFAAI 101,173,1962
    IPR-MUS LD50:7600 MG/KG                       PHTHDT 5,467,1979
    IVN-MUS LD50:4500 MG/KG                       ARZNAD 18,666,1968
    ORL-MAM LD50:25 GM/KG                         ZYZAEU 26,459,1991
    IVN-MAM LD50:5800 MG/KG                       ZYZAEU 26,459,1991
  TARGET ORGAN DATA
    BEHAVIORAL (ALTERED SLEEP TIME)
    CARDIAC (OTHER CHANGES)
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.
SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.
SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF
    THIS MATERIAL.
    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.
SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION.
SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
  EUROPEAN INFORMATION
    CAUTION: SUBSTANCE NOT YET FULLY TESTED.
  REVIEWS, STANDARDS, AND REGULATIONS
    OEL=MAK
    EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
     FEREAC 54,7740,1989
    NOHS 1974: HZD 80605; NIS 18; TNF 1388; NOS 32; TNE 24861
    NOES 1983: HZD X8582; NIS 38; TNF 6365; NOS 70; TNE 162120; TFE 112349
    EPA TSCA SECTION 8(B) CHEMICAL INVENTORY
    EPA TSCA SECTION 8(D) UNPUBLISHED HEALTH/SAFETY STUDIES
    EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
    NTP CARCINOGENESIS STUDIES (FEED);EQUIVOCAL EVIDENCE:RAT
     NTPTR* NTP-TR-415,1992
    NTP CARCINOGENESIS STUDIES (FEED);NO EVIDENCE:MOUSE
     NTPTR* NTP-TR-415,1992
SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT TO
    BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SIGMA, ALDRICH,
    FLUKA SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT. SEE REVERSE SIDE OF INVOICE OR
    PACKING SLIP FOR ADDITIONAL TERMS AND CONDITIONS OF SALE.
    COPYRIGHT 2001 SIGMA-ALDRICH CO.
    LICENSE GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY