Acetone 89909 **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION **** MSDS Name: Acetone Catalog Numbers: 57025 Synonyms: Dimethylformaldehyde, dimethyl ketone, 2-propanone, pyroacetic acid, pyroacetic ether Company Identification: Biochemical Sciences, Inc. 100 Clarendon Drive Swedesboro, NJ 08085 For information, call: 800-524-0294 Emergency Number: 800-524-0294 For CHEMTREC assistance, call: 800-424-9300 For International CHEMTREC assistance, call: 703-527-3887 **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS **** +----------------+--------------------------------------+----------+-----------+ | CAS# | Chemical Name | % | EINECS# | |----------------|--------------------------------------|----------|-----------| | 67-64-1 |Acetone | 100.0 | 200-662-2 | +----------------+--------------------------------------+----------+-----------+ Hazard Symbols: F Risk Phrases: 11 **** SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Appearance: colourless. Flash Point: -4 deg F. Danger! Extremely flammable liquid. May cause central nervous system depression. May cause liver and kidney damage. Causes eye and skin irritation. Causes digestive and respiratory tract irritation. Target Organs: Kidneys, central nervous system, liver. Potential Health Effects Eye: Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. Skin: Exposure may cause irritation characterized by redness, dryness, and inflammation. Ingestion: May cause irritation of the digestive tract. Symptoms may include: headache, excitement, fatigue, nausea, vomiting, stupor, and coma. May cause liver and kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. May cause liver and kidney damage. May cause motor incoordination and speech abnormalities. Chronic: Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation may cause effects similar to those of acute inhalation. **** SECTION 4 - FIRST AID MEASURES **** Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid immediately. Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. **** SECTION 5 - FIRE FIGHTING MEASURES **** General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Extremely flammable liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May be ignited by heat, sparks, and flame. Containers may explode when heated. Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out. Autoignition Temperature: 869 deg F ( 465.00 deg C) Flash Point: -4 deg F ( -20.00 deg C) (estimated) Health: 1; Flammability: 3; Reactivity: 0 Explosion Limits, Lower: 2.5 Upper: 12.8 **** SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Remove all sources of ignition. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces. **** SECTION 7 - HANDLING and STORAGE **** Handling: Wash thoroughly after handling. Use only in a well ventilated area. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Exposure Limits +--------------------+-------------------+-------------------+-----------------+ | Chemical Name | ACGIH | NIOSH |OSHA - Final PELs| |--------------------|-------------------|-------------------|-----------------| | Acetone |500 ppm ; 1188 |250 ppm TWA; 590 |1000 ppm TWA; | | | mg/m3; 750 ppm | mg/m3 TWA 2500 | 2400 mg/m3 TWA | | |STEL; 1782 mg/m3 | ppm IDLH (lower | | | | STEL | explosive level) | | +--------------------+-------------------+-------------------+-----------------+ OSHA Vacated PELs: Acetone: 750 ppm TWA; 1800 mg/m3 TWA Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Liquid Appearance: colourless Odor: sweetish odor pH: 7 Vapor Pressure: 180 mm Hg Vapor Density: 2.0 (Air=1) Evaporation Rate: 7.7 (n-Butyl acetate=1) Viscosity: Not available Boiling Point: 133.2 deg F Freezing/Melting Point: -139.6 deg F Decomposition Temperature: Not available. Solubility: Soluble. Specific Gravity/Density: 0.79 (Water=1) Molecular Formula: C3H6O Molecular Weight: 58.0414 **** SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable. Conditions to Avoid: High temperatures, temperatures above 220¦C. Incompatibilities with Other Materials: Acids (mineral, non-oxidizing, e.g. hydrochloric acid, hydrofluoric acid, muriatic acid, phosphoric acid), acids (mineral, oxidizing, e.g. chromic acid, hypochlorous acid, nitric acid, sulfuric acid), azo, diazo, and hydrazines (e.g. dimethyl hydrazine, hydrazine, methyl hydrazine), caustics (e.g. ammonia, ammonium hydrozide, calcium hydroxide, potassium hydroxide, sodium hydroxide), cyanides (e.g. potassium cyanide, sodium cyanide), mercaptans and other organic sulfides (e.g. butyl mercaptan, carbon disulfide, methanethiol), metals (alkali and alkaline, e.g. cesium, potassium, sodium), nitrides (e.g. potassium nitride, sodium nitride), peroxides and hydroperoxides (organic, e.g. acetyl peroxide, benzoyl peroxide, butyl peroxide, methyl ethyl ketone peroxide), oxidizing agents (strong, e.g. bromine, hydrogen peroxide, nitrogen dioxide, potassium nitrate), reducing agents (strong, e.g. aluminum carbide, chlorosilane, hydrogen phosphide, lithium hydride), water reactive substances (e.g. acetic anyhdride, alkyl aluminum chloride, calcium carbide, ethyl dichlorosilane). Hazardous Decomposition Products: Carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported. **** SECTION 11 - TOXICOLOGICAL INFORMATION **** RTECS#: CAS# 67-64-1: AL3150000 LD50/LC50: CAS# 67-64-1: Inhalation, rat: LC50 =50100 mg/m3/8H; Oral, mouse: LD50 = 3 gm/kg; Oral, rabbit: LD50 = 5340 mg/kg; Oral, rat: LD50 = 5800 mg/kg; Skin, rabbit: LD50 = 20 gm/kg. Carcinogenicity: Acetone - ACGIH: A4 - Not Classifiable as a Human Carcinogen Epidemiology: No data available. Teratogenicity: No data available. Reproductive Effects: No data available. Neurotoxicity: No data available. Mutagenicity: No data available. Other Studies: None. **** SECTION 12 - ECOLOGICAL INFORMATION **** Ecotoxicity: Rainbow trout LC50=5540 mg/L/96H Sunfish (tap water), death at 14250 ppm/24H Mosquito fish (turbid water) TLm=13000 ppm/48H Environmental Fate: Volatilizes, leeches, and biodegrades when released to soil. Physical/Chemical: No information available. Other: None. **** SECTION 13 - DISPOSAL CONSIDERATIONS **** Dispose of in a manner consistent with federal, state, and local regulations. RCRA D-Series Maximum Concentration of Contaminants: None listed. RCRA D-Series Chronic Toxicity Reference Levels: None listed. RCRA F-Series: None listed. RCRA P-Series: None listed. RCRA U-Series: CAS# 67-64-1: waste number U002 (Ignitable waste). CAS# 67-64-1 is banned from land disposal according to RCRA. **** SECTION 14 - TRANSPORT INFORMATION **** US DOT No information available IMO No information available. IATA No information available. RID/ADR No information available. Canadian TDG Shipping Name: ACETONE Hazard Class: 3 UN Number: UN1090 Other Information: FLASHPOINT -20 C **** SECTION 15 - REGULATORY INFORMATION **** US FEDERAL TSCA CAS# 67-64-1 is listed on the TSCA inventory. Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b CAS# 67-64-1: export notification required - Section 4 TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. SARA Section 302 (RQ) CAS# 67-64-1: final RQ = 5000 pounds (2270 kg) Section 302 (TPQ) None of the chemicals in this product have a TPQ. SARA Codes CAS # 67-64-1: acute, chronic, flammable, sudden release of pressure. Section 313 No chemicals are reportable under Section 313. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE Acetone can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: F Risk Phrases: R 11 Highly flammable. Safety Phrases: S 16 Keep away from sources of ignition - No smoking. S 33 Take precautionary measures against static discharges. S 9 Keep container in a well-ventilated place. S 23C Do not breathe vapour. WGK (Water Danger/Protection) CAS# 67-64-1: 0 Canada CAS# 67-64-1 is listed on Canada's DSL/NDSL List. This product has a WHMIS classification of B2, D2B. CAS# 67-64-1 is not listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 67-64-1: OEL-AUSTRALIA:TWA 500 ppm (1185 mg/m3);STEL 1000 ppm OEL-AUSTRIA:TWA 750 ppm (1780 mg/m3) OEL-BELGIUM:TWA 750 ppm (1780 mg/m3);STEL 1000 pp OEL-CZECHOSLOVAKIA:TWA 800 mg/m3;STEL 4000 mg/m3 OEL-DENMARK:TWA 250 ppm (600 mg/m3) OEL-FINLAND:TWA 500 ppm (1200 mg/m3);STEL 625 ppm (1500 mg/m3) OEL-FRANCE:TWA 750 ppm (1800 mg/m3) OEL-GERMANY:TWA 1000 ppm (2400 mg/m3) OEL-HUNGARY:TWA 600 mg/m3;STEL 1200 mg/m3 OEL-INDIA:TWA 750 ppm (1780 mg/m3);STEL 1000 ppm (2375 mg/m3) OEL-JAPAN:TWA 200 ppm (470 mg/m3) OEL-THE NETHERLANDS:TWA 750 ppm (1780 mg/m3) JAN9 OEL-THE PHILIPPINES:TWA 1000 ppm (2400 mg/m3) OEL-POLAND:TWA 200 mg/m3 OEL-RUSSIA:TWA 200 ppm;STEL 200 mg/m3 OEL-SWEDEN:TWA 250 ppm (600 mg/m3);STEL 500 ppm (1200 mg/m3) OEL-SWITZERLAND:TWA 750 ppm (1780 mg/m3) OEL-TURKEY:TWA 1000 ppm (2400 mg/m3) OEL-UNITED KINGDOM:TWA 1000 ppm (2400 mg/m3);STEL 1250 ppm OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV **** SECTION 16 - ADDITIONAL INFORMATION **** MSDS Creation Date: 3/04/1998 Revision #0 Date: Original. The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages. --------------------------------------------------------------------------------