Connecticut College offers students an unusually wide range of opportunities to explore a topic, issue or problem using the conceptual framework and tools of more than one academic discipline. Students may choose an established interdisciplinary major or design one in consultation with faculty advisers and the Committee on Student-Designed Interdisciplinary Majors and Minors.

Students in any major may also earn a certificate from one of the College's innovative interdisciplinary centers. Requirements for the certificate programs include a challenging combination of coursework, in-depth research and a funded summer internship in the U.S. or abroad. The four centers are:

- Ammerman Center for Arts and Technology
- Goodwin-Niering Center for the Environment
- Holleran Center for Community Action and Public Policy
- Toor Cummings Center for International Studies and the Liberal Arts (CISLA)

A fifth center, the Center for the Comparative Study of Race and Ethnicity, was established in 2005 as a hub for researching and teaching race and ethnicity across the disciplines.