"Dr. Zimmer has written the first overview of one of history's most important revolutions in biology and medicine.... The wonderful future that fluorescent proteins will bring us cannot even be imagined at this point."
Robert M. Hoffman, Ph.D.
President, AntiCancer, Inc.
"Marc Zimmer tells the fascinating story about how a curiosity of nature, animals that glow in the night, has lead to major technological advancements in the molecular biology revolution. This book reveals how academic inquiry can improve the quality of our lives in surprising ways."
Research Fellow, Promega Corporation
"Many countermeasures currently being developed against chemical and biological threats posed by international terrorism rely directly or indirectly upon the discoveries described so elegantly in this book."
Keith B. Ward, Ph.D., Science Advisor and Program Manager,
Homeland Security Advanced Research Projects Agency,
U. S. Department of Homeland Security
"For most of us biotechnology is a great mystery, sometimes presented as a frightening use of science when, in fact, it will greatly improve the ability of the earth to feed us all and also help us live long, healthier lives. Glowing Genes: A Revolution in Biotechnology ($28.00, Prometheus Books) by Dr. Marc Zimmer, Ph.D., may seem too exotic to even contemplate reading, but it will prove to be easily understood as it describes an amazing new area of biotechnology that will help fight cancer, create new products, improve agriculture, and even combat terrorism. The subject of the book is a green fluorescent protein that has existed in one species of jellyfish that, in 1994, was cloned, giving rise to potentially revolutionary applications. Imagine a glowing gene that lights up in the presence of anthrax spores and other chemical warfare agents? Imagine a gene that causes crops to glow, indicating they need more water? In the future, people who have long since been accustomed to their use will wonder how we ever lived without them."
Bookviews by Alan Caruba, March 2005
Marc Zimmer has written the first popular science book on an amazing new area of biotechnology that will help fight cancer, create new products, improve agriculture, and combat terrorism. For more than one hundred and sixty million years, green fluorescent protein has existed in one species of jellyfish. In 1994 it was cloned, giving rise to a host of useful and potentially revolutionary applications in biotechnology. Today researchers are using this ancient glowing protein to pursue exciting new discoveries, from tracking the process of bacterial infection to detecting chemical and biological agents planted by terrorists.
A recognized expert in this field, Zimmer begins with an overview of the many uses of these glowing genes to kill and image cancer cells, monitor bacterial infections, and light up in the presence of pollution. He then discusses the biological reasons that glowing proteins first evolved in jellyfish and fireflies, and looks at the history of bioluminescence and the dedicated scientists who devoted their careers to explaining this phenomenon. The story of how "glowing genes" were located, cloned, and then mass-produced is in itself a fascinating tale.
Zimmer next turns to the serious, and not-so-serious, uses of fluorescent proteins. In agriculture it may soon be possible to produce crops that signal dryness by glowing. In industry a red fluorescent protein originally found in corals may find a use in sheep as a substitute for environmentally harmful wool dyes.
Furthermore, the glowing gene revolution has led to significantly more humane treatment of laboratory animals. No longer must animal lives be sacrificed to understand disease processes; now researchers can observe the spread of cancer and infections by treating animals with green fluorescent genes and similar proteins.
In the fight against terrorism a glowing gene has been created that lights up in the presence of anthrax spores, chemical warfare agents, and landmines. And in a completely different arena, we have already seen the emergence of "transgenic art" in Alba, the fluorescent bunny rabbit.
Glowing Genes is a highly informative, fascinating, and entertaining read about a burgeoning area of biotechnology that promises soon to revolutionize our world.